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Global genetic differentiation of complex traits shaped by natural selection in humans [Nature Communications]

Keywords : evolutionary genetics, genetic association study

par Frédéric Magné - publié le

There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to 405,000).(...)

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